Experimental designs and their recent advances in set-up, data interpretation, and analytical applications

B Dejaegher, Y Vander Heyden - Journal of pharmaceutical and …, 2011 - Elsevier
In this review, the set-up and data interpretation of experimental designs (screening,
response surface, and mixture designs) are discussed. Advanced set-ups considered are …

Application of factorial and response surface methodology in modern experimental design and optimization

G Hanrahan, K Lu - Critical reviews in analytical chemistry, 2006 - Taylor & Francis
This article critically examines the use of factorial and response surface methodology in
modern experimental design and optimization. A survey of important screening and …

Design of experiments: concept and applications of Plackett Burman design

K Vanaja, RH Shobha Rani - Clinical research and regulatory …, 2007 - Taylor & Francis
Application of statistics has broadened far beyond its origin to various areas of research and
one among them is the design of experiments. Design of experiments gathers the maximum …

Enantioseparations in capillary electromigration techniques: recent developments and future trends

B Chankvetadze, G Blaschke - Journal of Chromatography A, 2001 - Elsevier
This review summarizes the current status of enantioseparations using capillary
electromigration techniques and gives the authors insights on the selected fundamental …

Ruggedness and robustness testing

B Dejaegher, Y Vander Heyden - Journal of chromatography A, 2007 - Elsevier
Due to the strict regulatory requirements, especially in pharmaceutical analysis, analysis
results with an acceptable quality should be reported. Thus, a proper validation of the …

Application of statistical 'design of experiments' methods in drug discovery

H Tye - Drug discovery today, 2004 - Elsevier
The use of 'design of experiments'(DoE) is a revolutionary approach to optimisation and
screening of experimental parameters. Simple experimental designs and statistical tools for …

Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

A Amini - Electrophoresis, 2001 - Wiley Online Library
This paper provides an overview of the current status of chiral capillary electrophoresis (CE).
The emphasis is placed on the application of CE in chiral separation of various racemic …

Application of experimental design methodologies in the enantioseparation of pharmaceuticals by capillary electrophoresis: A review

G Hancu, S Orlandini, LA Papp, A Modroiu, R Gotti… - Molecules, 2021 - mdpi.com
Chirality is one of the major issues in pharmaceutical research and industry. Capillary
electrophoresis (CE) is an interesting alternative to the more frequently used …

Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and …

E Nemutlu, S Kır, D Katlan, MS Beksac - Talanta, 2009 - Elsevier
An HPLC method for the separation of seven cephalosporins [Cefepime (CEP), ceftazidime
(CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and …

Selected fundamental aspects of chiral electromigration techniques and their application to pharmaceutical and biomedical analysis

GKE Scriba - Journal of pharmaceutical and biomedical analysis, 2002 - Elsevier
While capillary electrophoresis has been established as a major enantioseparation
technique within the last decade, the potential of capillary electrochromatography is still …