Preconditioning Stem Cells for In Vivo Delivery

S Sart, T Ma, Y Li - BioResearch open access, 2014 - liebertpub.com
Stem cells have emerged as promising tools for the treatment of incurable neural and heart
diseases and tissue damage. However, the survival of transplanted stem cells is reported to …

Controlling redox status for stem cell survival, expansion, and differentiation

S Sart, L Song, Y Li - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
Reactive oxygen species (ROS) have long been considered as pathological agents
inducing apoptosis under adverse culture conditions. However, recent findings have …

[HTML][HTML] Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: current technologies and challenges

AC Schnitzler, A Verma, DE Kehoe, D Jing… - Biochemical …, 2016 - Elsevier
The long-term outlook for regenerative medicine predicts an increased need for scalable cell
expansion technologies that utilize non-animal derived materials and are compatible with …

Digital twins for tissue culture techniques—concepts, expectations, and state of the art

J Möller, R Pörtner - Processes, 2021 - mdpi.com
Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

A xeno‐free microcarrier‐based stirred culture system for the scalable expansion of human mesenchymal stem/stromal cells isolated from bone marrow and adipose …

JG Carmelo, A Fernandes‐Platzgummer… - Biotechnology …, 2015 - Wiley Online Library
Human mesenchymal stem/stromal cells (MSC) are promising candidates for cell‐based
therapies and the development of microcarrier‐based cultures in scalable bioreactors with …

Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors

S Sart, SN Agathos, Y Li, T Ma - Biotechnology journal, 2016 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) have emerged as an important cell type in cell
therapy and tissue engineering. In these applications, maintaining the therapeutic properties …

Genomics analysis of metabolic pathways of human stem cell‐derived microglia‐like cells and the integrated cortical spheroids

J Bejoy, X Yuan, L Song, T Hua, R Jeske… - Stem Cells …, 2019 - Wiley Online Library
Brain spheroids or organoids derived from human pluripotent stem cells (hiPSCs) are still
not capable of completely recapitulating in vivo human brain tissue, and one of the …

Mitohormesis and mitochondrial dynamics in the regulation of stem cell fate

A Barzegari, S Aaboulhassanzadeh… - Journal of Cellular …, 2022 - Wiley Online Library
The ability of stem cells for self‐renewing, differentiation, and regeneration of injured tissues
is believed to occur via the hormetic modulation of nuclear/mitochondrial signal …

Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: focus on mesenchymal stem cells and neuroprotection

F Yousefi, FL Arab, K Saeidi, H Amiri… - Journal of …, 2019 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which predominantly affect young adults and undergo heavy socioeconomic …

[HTML][HTML] The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness

R Soh, A Hardy, NI Zur Nieden - Free Radical Biology and Medicine, 2021 - Elsevier
Previous views of reactive oxygen species (ROS) depicted them as harmful byproducts of
metabolism as uncontrolled levels of ROS can lead to DNA damage and cell death …