The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …

Neurons in the central nervous system (CNS) are terminally differentiated cells that
gradually lose their ability to support regeneration during maturation due to changes in …

Background Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic,
chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The …

Adult central nervous system (CNS) axons fail to regenerate after injury, and master
regulators of the regenerative program remain to be identified. We analyzed the …

Background Optic-nerve injury results in impaired transmission of visual signals to central
targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss …

In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive
or regenerate their optic nerve axons underlies partial and, in some cases, complete vision …

Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs),
degenerate and die after injury. Early axon protein and organelle trafficking failure is a key …

Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after
optic nerve injury and surviving RGCs fail to regenerate their axons, eventually resulting in …

Injury to the central nervous system (CNS) often results in permanent neurological
impairments because axons fail to regenerate and re-establish lost synaptic contacts. By …

Glucocorticoids, vertebrate steroid hormones produced by cells of the adrenal cortex or
interrenal tissue, function dynamically to maintain homeostasis under constantly changing …