Clostridioides difficile infection in children: Recent updates on epidemiology, diagnosis, therapy

DA Shirley, W Tornel, CA Warren, S Moonah - Pediatrics, 2023 - publications.aap.org
Clostridioides (formerly Clostridium) difficile is the most important infectious cause of
antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated …

Recent advances in Clostridioides difficile infection epidemiology, diagnosis and treatment in children

LK Kociolek, JD Crews… - Current Opinion in …, 2021 - journals.lww.com
Recent advances in Clostridioides difficile infection epidem... : Current Opinion in Infectious
Diseases Recent advances in Clostridioides difficile infection epidemiology, diagnosis and …

Microbial etiologies and clinical characteristics of children seeking emergency department care due to vomiting in the absence of diarrhea

SB Freedman, J Xie, BE Lee, S Ali… - Clinical Infectious …, 2021 - academic.oup.com
Background As children with isolated vomiting are rarely able to provide a specimen
suitable for routine pathogen testing, we have limited knowledge about their infecting …

Clinical impact of a diagnostic gastrointestinal panel in children

JM Cotter, J Thomas, M Birkholz, L Ambroggio… - …, 2021 - publications.aap.org
OBJECTIVES: Many hospitals have transitioned from conventional stool diagnostics to rapid
multiplex polymerase chain reaction gastrointestinal panels (GIP). The clinical impact of this …

Variation in stool testing for children with acute gastrointestinal infections

JL Markham, M Hall, ME Collins… - Journal of Hospital …, 2023 - Wiley Online Library
Abstract Background and Objective Children with gastrointestinal infections often require
acute care. The objectives of this study were to describe variations in patterns of stool testing …

A Multimodal Intervention to Reduce C. difficile Infections and Stool Testing

JM Cotter, CL Stokes, S Tong, M Birkholz, J Child… - …, 2024 - publications.aap.org
METHODS We conducted a quality improvement project from 2018 to 2020 at a large
children's hospital. Interventions included development of a C. difficile testing and treatment …

Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches

MZ Alam, JE Markantonis, JT Fallon - Tropical Medicine and Infectious …, 2023 - mdpi.com
Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial
public health challenge within the United States and globally. CDI typically occurs in …

Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children

EC Ho, JM Cotter, J Thomas, M Birkholz… - Hospital …, 2023 - publications.aap.org
OBJECTIVES There is uncertainty regarding which hospitalized patients with acute
gastroenteritis (AGE) benefit from gastrointestinal panel (GIP) testing. Unnecessary testing …

Pediatric Clostridioides difficile Infection: Diagnosis and Diagnostic Stewardship

HT Schwenk, NR Pollock… - Journal of the Pediatric …, 2021 - academic.oup.com
Although the pathogenesis of Clostridioides difficile infection (CDI) is complex and
incompletely understood, it is believed that the elaboration of C. difficile toxins is necessary …

Enteric pathogen testing importance for children with acute gastroenteritis: a modified Delphi study

GAM Tarr, DJ Persson, PI Tarr… - Microbiology …, 2022 - Am Soc Microbiol
The application of clinical diagnostics for gastroenteritis in children has implications for a
broad collection of stakeholders, impacting clinical care, communicable disease control, and …