The dynamic gastric environment and its impact on drug and formulation behaviour

J Van den Abeele, J Rubbens, J Brouwers… - European Journal of …, 2017 - Elsevier
Before being absorbed in the small intestine and/or colon, orally administered drugs
inevitably need to pass through the stomach. Hence, it seems reasonable that the residence …

Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds

V Kalidasan, X Yang, Z Xiong, RR Li, H Yao… - Nature Biomedical …, 2021 - nature.com
Monitoring surgical wounds post-operatively is necessary to prevent infection, dehiscence
and other complications. However, the monitoring of deep surgical sites is typically limited to …

Impact of acid-reducing agents on gastrointestinal physiology and design of biorelevant dissolution tests to reflect these changes

D Segregur, T Flanagan, J Mann, A Moir… - Journal of …, 2019 - Elsevier
Background Of the various drug therapies that influence gastrointestinal (GI) physiology, one
of the most important are the acid-reducing agents (ARAs). Because changes in GI …

[HTML][HTML] Salivary pepsin as an intrinsic marker for diagnosis of sub-types of gastroesophageal reflux disease and gastroesophageal reflux disease-related disorders

YJ Wang, XQ Lang, D Wu, YQ He, CH Lan… - Journal of …, 2020 - ncbi.nlm.nih.gov
Methods Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC)
were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) …

Stability of plant virus-based nanocarriers in gastrointestinal fluids

A Berardi, DJ Evans, FB Bombelli, GP Lomonossoff - Nanoscale, 2018 - pubs.rsc.org
Cowpea mosaic virus (CPMV) is a plant virus which is being extensively investigated as a
drug delivery and vaccine nanocarrier for parenteral administration. However, to date little is …

Gastric fluid composition in a paediatric population: age-dependent changes relevant for gastrointestinal drug disposition

J Van Den Abeele, M Rayyan, I Hoffman… - European Journal of …, 2018 - Elsevier
This work aimed to (i) expand the dataset on gastric fluid composition in the paediatric
population (0–18 years old) and (ii) improve our understanding of age-dependent changes …

[HTML][HTML] Production and transepithelial transportation of angiotensin-I-converting enzyme (ACE)-inhibitory peptides from whey protein hydrolyzed by immobilized …

Y Guo, X Jiang, B Xiong, T Zhang, X Zeng, Z Wu… - Journal of dairy …, 2019 - Elsevier
Lactobacillus helveticus LB 10 proteinases immobilized with sodium alginate were used to
hydrolyze whey protein to produce angiotensin-I-converting enzyme (ACE)-inhibitory …

Pepsin triggers neutrophil migration across acid damaged lung epithelium

BP Hurley, RH Jugo, RF Snow, TL Samuels… - Scientific reports, 2019 - nature.com
Pepsin represents a potential biomarker for extraesophageal reflux disease when detected
in airways, however a direct role for pepsin in lung dysfunction has not been clearly …

Stability of rosmarinic acid in aqueous extracts from different Lamiaceae species after in vitro digestion with human gastrointestinal enzymes

Z Zorić, J Markić, S Pedisić… - Food technology and …, 2016 - hrcak.srce.hr
Sažetak The present study compares the gastrointestinal stability of rosmarinic acid in
aqueous extracts of thyme, winter savory and lemon balm with the stability of pure …

Association between regular use of gastric acid suppressants and subsequent risk of cholelithiasis: a prospective cohort study of 0.47 million participants

M Yang, B Xia, Y Lu, Q He, Y Lin, P Yue… - Frontiers in …, 2022 - frontiersin.org
Background: Gastric acid suppressants have a major impact on gut microbiome which in
turn, may increase the risk of cholelithiasis, but epidemiological evidence remains unclear …