A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

Y Gao, R Liu, CW Chang, S Charyyev… - Journal of Applied …, 2022 - Wiley Online Library
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

H Kacem, A Almeida, N Cherbuin… - International journal of …, 2022 - Taylor & Francis
A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …

Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications

L Whitmore, RI Mackay, M Van Herk, JK Jones… - Scientific Reports, 2021 - nature.com
This paper presents the first demonstration of deeply penetrating dose delivery using
focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo …

VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint

HC Wanstall, P Korysko, W Farabolini, R Corsini… - Scientific Reports, 2024 - nature.com
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy
tissue, an effect known as 'FLASH'. This effect has been studied across several radiation …

FLASH radiotherapy: an emerging approach in radiation therapy

N Matuszak, WM Suchorska, P Milecki… - reports of Practical …, 2022 - journals.viamedica.pl
FLASH radiotherapy (RT) is a technique involving the delivery of ultra-high dose rate
radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity in …

Treatment planning for Flash radiotherapy: General aspects and applications to proton beams

M Schwarz, E Traneus, S Safai, A Kolano… - Medical …, 2022 - Wiley Online Library
The increased radioresistence of healthy tissues when irradiated at very high dose rates
(known as the Flash effect) is a radiobiological mechanism that is currently investigated to …

FLASHlab@ PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ

F Stephan, M Gross, A Grebinyk, Z Aboulbanine… - Physica medica, 2022 - Elsevier
Abstract At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for
electron FLASH and very high energy electron radiation therapy and radiation biology is …

Out-of-field measurements and simulations of a proton pencil beam in a wide range of dose rates using a Timepix3 detector: Dose rate, flux and LET

C Oancea, C Granja, L Marek, J Jakubek, J Šolc… - Physica Medica, 2023 - Elsevier
Stray radiation produced by ultra-high dose-rates (UHDR) proton pencil beams is
characterized using ASIC-chip semiconductor pixel detectors. A proton pencil beam with an …

Specification and design for full energy beam exploitation of the compact linear accelerator for research and applications

EW Snedden, D Angal-Kalinin, AR Bainbridge… - … Review Accelerators and …, 2024 - APS
The compact linear accelerator for research and applications (CLARA) is a 250 MeV
ultrabright electron beam test facility at STFC Daresbury Laboratory. A user beamline has …

[HTML][HTML] Quantifying the DNA-damaging effects of FLASH irradiation with plasmid DNA

A Perstin, Y Poirier, A Sawant, M Tambasco - International Journal of …, 2022 - Elsevier
Purpose To investigate a plasmid DNA nicking assay approach for isolating and quantifying
the DNA-damaging effects of ultrahigh-dose-rate (ie, FLASH) irradiation relative to …