NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
The potential of organometallic complexes in medicinal chemistry
G Gasser, N Metzler-Nolte - Current opinion in chemical biology, 2012 - Elsevier
Organometallic complexes have unique physico-chemical properties, which have been
widely used in homogenous catalysis, for example, for the synthesis of lead compounds and …
widely used in homogenous catalysis, for example, for the synthesis of lead compounds and …
Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
S Leijen, SA Burgers, P Baas, D Pluim, M Tibben… - Investigational new …, 2015 - Springer
Summary Background This phase I/II study determined the maximal tolerable dose, dose
limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics of …
limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics of …
Anticancer cyclometalated complexes of platinum group metals and gold
N Cutillas, GS Yellol, C de Haro, C Vicente… - Coordination chemistry …, 2013 - Elsevier
The clinical success of cisplatin and its derivatives has had an enormous impact on the
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …
Metal compounds against neglected tropical diseases
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …
Organization (WHO) are limited by one or more of the following: the development of drug …
The choice of μ-vinyliminium ligand substituents is key to optimize the antiproliferative activity of related diiron complexes
B Campanella, S Braccini, G Bresciani… - Metallomics, 2023 - academic.oup.com
Diiron vinyliminium complexes constitute a large family of organometallics displaying a
promising anticancer potential. The complexes [Fe2Cp2 (CO)(μ-CO){μ-η1: η3-C (R3) C (R4) …
promising anticancer potential. The complexes [Fe2Cp2 (CO)(μ-CO){μ-η1: η3-C (R3) C (R4) …
N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and …
G Bresciani, J Cervinka, H Kostrhunova… - Chemico-Biological …, 2023 - Elsevier
The indole scaffold has been established as a key organic moiety for developing new drugs;
on the other hand, a range of diiron bis-cyclopentadienyl complexes have recently emerged …
on the other hand, a range of diiron bis-cyclopentadienyl complexes have recently emerged …
Nanomedicines in the treatment of colon cancer: A focus on metallodrugs
P Farinha, JO Pinho, M Matias, MM Gaspar - Drug Delivery and …, 2022 - Springer
Worldwide, colon cancer (CC) represents the fourth most common type of cancer and the
fifth major cause of cancer-associated deaths. Surgical resection is considered the standard …
fifth major cause of cancer-associated deaths. Surgical resection is considered the standard …
Ligand Design for N,O- or N,N-Pyrazolone-Based Hydrazones Ruthenium(II)-Arene Complexes and Investigation of Their Anticancer Activity
Three pyrazolone-based hydrazone ligands HL′(HL′ in general; in detail, HL1= 2-((5-
hydroxo-3-methyl-1-phenyl-1 H-pyrazol-4-yl)(phenyl) methylene)-1-(2, 4-nitrophenyl) …
hydroxo-3-methyl-1-phenyl-1 H-pyrazol-4-yl)(phenyl) methylene)-1-(2, 4-nitrophenyl) …
Easily available, amphiphilic diiron cyclopentadienyl complexes exhibit in vitro anticancer activity in 2D and 3D human cancer cells through redox modulation …
L Biancalana, M De Franco… - … A European Journal, 2021 - Wiley Online Library
A straightforward two‐step procedure via single CO removal allows the conversion of
commercial [Fe2Cp2 (CO) 4] into a range of amphiphilic and robust ionic complexes based …
commercial [Fe2Cp2 (CO) 4] into a range of amphiphilic and robust ionic complexes based …