B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor
N Chiorazzi, M Ferrarini - Annual review of immunology, 2003 - annualreviews.org
B cell chronic lymphocytic leukemia (B-CLL) is an accumulative disease of slowly
proliferating CD5+ B lymphocytes that develops in the aging population. Whereas some …
proliferating CD5+ B lymphocytes that develops in the aging population. Whereas some …
B-cell chronic lymphocytic leukemia: a bird of a different feather
F Caligaris-Cappio, TJ Hamblin - Journal of clinical oncology, 1999 - ascopubs.org
PURPOSE: To review the recent major advances in the molecular and cell biology of B-cell
chronic lymphocytic leukemia (B-CLL). METHODS: We analyzed the nature of malignant B …
chronic lymphocytic leukemia (B-CLL). METHODS: We analyzed the nature of malignant B …
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
SEM Herman, AL Gordon, E Hertlein… - Blood, The Journal …, 2011 - ashpublications.org
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia
(CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse …
(CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse …
Analysis of cycloheximide‐induced apoptosis in human leukocytes: Fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium …
D Baskić, S Popović, P Ristić… - Cell biology …, 2006 - Wiley Online Library
Apoptosis is a highly regulated and programmed cell breakdown process characterized by
numerous changes. Since it is implicated in many pathological as well as physiological …
numerous changes. Since it is implicated in many pathological as well as physiological …
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
P Panayiotidis, D Jones, K Ganeshaguru… - British journal of …, 1996 - Wiley Online Library
Leukaemic cells from most cases of B‐chronic lymphocytic leukaemia die rapidly by
apoptosis in vitro unless they are cultured in the presence of interleukin‐4 or interferon α or …
apoptosis in vitro unless they are cultured in the presence of interleukin‐4 or interferon α or …
Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
C Calissano, RN Damle, S Marsilio, XJ Yan… - Molecular …, 2011 - Springer
The failure of chemotherapeutic regimens to eradicate cancers often results from the
outgrowth of minor subclones with more dangerous genomic abnormalities or with self …
outgrowth of minor subclones with more dangerous genomic abnormalities or with self …
CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
V Mateo, L Lagneaux, D Bron, G Biron, M Armant… - Nature medicine, 1999 - nature.com
Thrombospondin forms a'molecular bridge'between phagocytic and apoptotic cells through
interaction with αvβ3/CD36. We report here that engagement of CD47, a newly described …
interaction with αvβ3/CD36. We report here that engagement of CD47, a newly described …
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional …
JC Byrd, C Shinn, JK Waselenko… - Blood, The Journal …, 1998 - ashpublications.org
Flavopiridol has been reported to induce apoptosis in lymphoid cell lines via downregulation
of bcl-2. The in vitro activity of flavopiridol against human chronic lymphocytic leukemia …
of bcl-2. The in vitro activity of flavopiridol against human chronic lymphocytic leukemia …
miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors
B-cell receptor (BCR) signaling and T-cell interactions play a pivotal role in chronic
lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use …
lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use …
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from …
DR Richardson, K Milnes - Blood, The Journal of the American …, 1997 - ashpublications.org
We have recently screened 36 analogues of the lipophilic iron (Fe) chelator, pyridoxal
isonicotinoyl hydrazone (PIH), for their antiproliferative effect (Richardson et al, Blood 86 …
isonicotinoyl hydrazone (PIH), for their antiproliferative effect (Richardson et al, Blood 86 …