Unraveling the Molecular Complexity of N-Terminus Huntingtin Oligomers: Insights into Polymorphic Structures
Huntington's disease (HD) is a fatal neurodegenerative disorder resulting from an abnormal
expansion of polyglutamine (polyQ) repeats in the N-terminus of the huntingtin protein …
expansion of polyglutamine (polyQ) repeats in the N-terminus of the huntingtin protein …
Charge distribution and helical content tune the binding of septin [&prime] s amphipathic helix domain to lipid membranes
Septins are a class of cytoskeletal proteins that preferentially bind to domains of micron-
scale curvature on the cell membrane. Studies have shown that amphipathic helix (AH) …
scale curvature on the cell membrane. Studies have shown that amphipathic helix (AH) …
Investigating curvature sensing by the Nt17 domain of Huntingtin protein
Nt17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention
for its role in htt's membrane binding and aggregation processes. Previous studies have …
for its role in htt's membrane binding and aggregation processes. Previous studies have …
[PDF][PDF] Conformational landscapes of Huntingtin's polyQ domain and variations in its aggregate morphology
Huntington's disease is a fatal neurodegenerative disease caused by an aberrant polyQ
expansion in the Huntingtin protein (htt). In cases with polyQ≥ 35, the expanded polyQ tract …
expansion in the Huntingtin protein (htt). In cases with polyQ≥ 35, the expanded polyQ tract …
Investigating the curvature sensing ability of Huntingtin's N17 domain
N17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention
for its role in htt9s membrane binding and aggregation processes. Previous studies have …
for its role in htt9s membrane binding and aggregation processes. Previous studies have …