The emerging roles of CEACAM6 in human cancer
G Wu, D Wang, F Xiong, Q Wang… - International …, 2024 - spandidos-publications.com
Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a cell
adhesion protein of the CEA family of glycosyl phosphatidyl inositol anchored cell surface …
adhesion protein of the CEA family of glycosyl phosphatidyl inositol anchored cell surface …
Development and characterization of an anti-cancer monoclonal antibody for treatment of human carcinomas
K Tsang, M Fantini, SA Mavroukakis, A Zaki… - Cancers, 2022 - mdpi.com
Simple Summary Cancers can grow and spread to different parts of the body. The aim of
immunotherapy is to stimulate the immune system to eliminate cancer cells in a selective …
immunotherapy is to stimulate the immune system to eliminate cancer cells in a selective …
First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
CB Cole, MP Morelli, M Fantini, M Miettinen… - Journal of Experimental …, 2023 - Springer
Background NEO201 is a humanized IgG1 monoclonal antibody (mAb) generated against
tumor-associated antigens from patients with colorectal cancer. NEO-201 binds to core 1 or …
tumor-associated antigens from patients with colorectal cancer. NEO-201 binds to core 1 or …
Identification of the O-Glycan Epitope Targeted by the Anti-Human Carcinoma Monoclonal Antibody (mAb) NEO-201
KY Tsang, M Fantini, A Zaki, SA Mavroukakis… - Cancers, 2022 - mdpi.com
Simple Summary Glycosylation is an important post-translational modification made on
mammalian proteins and lipids. In cancer cells, the disruption of several glycosylation …
mammalian proteins and lipids. In cancer cells, the disruption of several glycosylation …
Generation of the therapeutic monoclonal antibody NEO-201, derived from a cancer vaccine, which targets human malignancies and immune suppressor cells
M Fantini, KY Tsang, PM Arlen - Expert Review of Vaccines, 2024 - Taylor & Francis
Introduction Cancer vaccines stimulate the activation of specific humoral and cellular
adaptive responses against cancer cells. Antibodies generated post vaccination can be …
adaptive responses against cancer cells. Antibodies generated post vaccination can be …
[HTML][HTML] Harnessing NK cells for cancer immunotherapy: immune checkpoint receptors and chimeric antigen receptors
Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed
with the unique ability to spontaneously eliminate cells undergoing a neoplastic …
with the unique ability to spontaneously eliminate cells undergoing a neoplastic …
Novel methylcellulose based thermosenstive in situ nano liposomes of docetaxel for improved pharmacokinetics and pharmacodynamics with reduced toxicity
The utility of Docetaxel (DTX) in different cancers is highly compromised due to reported
side effects from its commercial injectable formulation. In this work, novel methylcellulose …
side effects from its commercial injectable formulation. In this work, novel methylcellulose …
The protein landscape of mucinous ovarian cancer: towards a theranostic
A Youssef, MB Haskali, KL Gorringe - Cancers, 2021 - mdpi.com
Simple Summary Mucinous ovarian cancer (MOC) is a rare type of epithelial ovarian cancer,
and current treatment regimens for late stage and recurrent disease are inadequate. The …
and current treatment regimens for late stage and recurrent disease are inadequate. The …
Cancer Stem Cell Metastatic Checkpoints and Glycosylation Patterns: Implications for Therapeutic Strategies
SS Aghamiri, R Amin - Kinases and Phosphatases, 2024 - mdpi.com
Cancer stem cells (CSCs), found within tumors, are powerful drivers of disease recurrence
and metastasis. Their abilities to self-renew and maintain stem-like properties make …
and metastasis. Their abilities to self-renew and maintain stem-like properties make …