Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

Multipotent neural stem cells are present throughout the development of the central nervous
system (CNS), persist into adulthood in defined locations and can be derived from more …

Pediatric brain tumors are significant causes of morbidity and mortality. It has been
hypothesized that they derive from self-renewing multipotent neural stem cells. Here, we …

Robust type-I interferon (IFN-α/β) induction in plasmacytoid dendritic cells, through the
activation of Toll-like receptor 9 (TLR9), constitutes a critical aspect of immunity,,,,,. It is …

We compared gene expression profiles of mouse and human ES cells by
immunocytochemistry, RT-PCR, and membrane-based focused cDNA array analysis …

Sensory hair cells and their associated non-sensory supporting cells in the inner ear are
fundamental for hearing and balance. They arise from a common progenitor, but little is …

Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

Stem cells are highly abundant during early development but become a rare population in
most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a …

Differentiation of stem cells toward a neuronal lineage normally involves a gradually
progressive restriction in developmental potential and is regulated by a diverse set of …

The proliferative ventricular zone (VZ) is the main source of projection neurons for the
overlying cerebral neocortex. The number and diversity of neocortical neurons is …