Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

In the ongoing debates about eukaryogenesis—the series of evolutionary events leading to
the emergence of the eukaryotic cell from prokaryotic ancestors—members of the Asgard …

The movement of proteins between cellular compartments requires the orchestrated actions
of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever.
Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We …

Bisphenol A (BPA) is one of endocrine disrupting chemicals, being distributed widely in the
environment. We have been studying the low dose effects of BPA on murine forebrain …

Vacuolar-vesicular protein sorting (Vps) factors are involved in vesicular trafficking in
eukaryotic cells. We identified the missense mutation L967Q in Vps54 in the wobbler mouse …

The identification of novel molecular targets crucially involved in motor neuron
degeneration/survival is a necessary step for the development of hopefully more effective …

Coiled-coil and multisubunit tethers have emerged as key regulators of membrane traffic
and organellar architecture. The restricted subcellular localization of tethers and their ability …

Tethering factors are large protein complexes that capture transport vesicles and enable
their fusion with acceptor organelles at different stages of the endomembrane system …