Prostate cancer development involves corruption of the normal prostate transcriptional
network, following deregulated expression or mutation of key transcription factors. Here, we …

Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms.
Despite their importance, the identification of SVs in cancer genomes remains challenging …

Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of
proteins associated with multiple human cancers. They can act as transcriptional activators …

How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma
(MB), the most common type of embryonal tumour, remains elusive. Here we uncover a …

The tumor suppressor protein retinoblastoma (RB) is mechanistically linked to suppression
of transcription factor E2F1-mediated cell cycle regulation. For multiple tumor types, loss of …

Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of
castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study …

The homogeneity and heterogeneity in somatic mutations, copy number alterations and
methylation across different cancer types have been extensively explored. However, the …

The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark
capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis …

Abstract Purpose of Review An important number of newly identified molecular alterations in
prostate cancer affect gene encoding master regulators of chromatin biology epigenetic …

NCAPD3 is one of the non-SMC regulatory subunits of Condensin II, which is mainly
responsible for the condensation and segregation of chromosomes during mitosis. However …