To fulfill their nutritional requirement for iron, bacteria utilize various iron sources which
include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron …

Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-
dependent iron acquisition pathways are well established. Here we demonstrate a newly …

Heme serves as a co-factor in proteins involved in fundamental biological processes
including oxidative metabolism, oxygen storage and transport, signal transduction and drug …

Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …

Gram-negative bacteria use specific heme uptake systems, relying on outer membrane
receptors and excreted heme-binding proteins (hemophores) to scavenge and actively …

Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Bacterial hemophores are secreted to the extracellular medium, where they scavenge heme
from various hemoproteins due to their higher affinity for this compound, and return it to their …

Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently
sequestered in the human host during infection. Heme constitutes the largest iron reservoir …