Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Apolipoproteins are protein constituents of lipoproteins that transport cholesterol and fat in
circulation and are central to cardiovascular health and disease. Soluble apolipoproteins …

Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play
key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA …

Apolipoprotein (apo) AI is an organizing scaffold protein that is critical to high-density
lipoprotein (HDL) structure and metabolism, probably mediating many of its cardioprotective …

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL'; s
cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent …

Cross-linking coupled with mass spectrometry (XL-MS) has emerged as a powerful strategy
for the identification of protein–protein interactions, characterization of interaction regions …

Sporadic cases of apolipoprotein A-IV medullary amyloidosis have been reported. Here we
describe five families found to have autosomal dominant medullary amyloidosis due to two …

Apolipoproteins measured in plasma or serum are potential biomarkers for assessing
metabolic irregularities that are associated with the development of cardiovascular disease …

ApoA-I, the major protein of plasma high-density lipoprotein, removes cellular cholesterol
and protects against atherosclerosis. ApoA-I mutations can cause familial amyloidosis, a life …

Background: Nonenzymatic glycation of apolipoproteins plays a role in the pathogenesis of
the vascular complications of diabetes. Objectives: This study investigated whether …