Recent discoveries in cancer metabolism have revealed promising metabolic targets to
modulate cancer progression, drug response, and anti-cancer immunity. Combination …

The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …

Background Despite their revolutionary success in cancer treatment over the last decades,
immunotherapies encounter limitations in certain tumor types and patients. The efficacy of …

Purpose: No evidence exists as to whether type 2 diabetes mellitus (T2DM) impairs clinical
outcome from immune checkpoint inhibitors (ICI) in patients with solid tumors. Experimental …

Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …

The tumor microenvironment (TME) plays a pivotal role in the fate of cancer cells, and tumor-
infiltrating immune cells have emerged as key players in shaping this complex milieu …

Oral cavity carcinomas are the most frequent malignancies among head and neck
malignancies. Oral tumors include not only oral cancer cells with different potency and …

Preclinical models of cancer have long been paramount to understanding tumor
development and advancing the treatment of cancer. Creating preclinical models that mimic …

Tumor-derived extracellular vesicles (TDEs) have potential for therapeutic cancer vaccine
applications since they innately possess tumor-associated antigens, mediate antigen …

Metformin, a biguanide antidiabetic, has been studied for its repurposing effects in oncology.
Although a modest effect was observed in a single-agent regimen, metformin can synergize …