Linear-After-The-Exponential (LATE)–PCR: An advanced method of asymmetric PCR and its uses in quantitative real-time analysis
JA Sanchez, KE Pierce, JE Rice… - Proceedings of the …, 2004 - National Acad Sciences
Conventional asymmetric PCR is inefficient and difficult to optimize because limiting the
concentration of one primer lowers its melting temperature below the reaction annealing …
concentration of one primer lowers its melting temperature below the reaction annealing …
Methods for the detection of loss of heterozygosity
SN Lapidus, AP Shuber - US Patent 5,928,870, 1999 - Google Patents
This invention relates to methods useful for disease diagnosis by detecting loss of
heterozygosity in cellular samples containing a small amount of mutated genetic material …
heterozygosity in cellular samples containing a small amount of mutated genetic material …
Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
SN Lapidus, AP Shuber, KM Ulmer - US Patent 5,670,325, 1997 - Google Patents
54 METHOD FOR THE DETECTION OF FOREIGN PATENT DOCUMENTS CLONAL
POPULATIONS OF A-11325/95 10/1994 Australia. TRANSFORMED CELLS INA 0284362 …
POPULATIONS OF A-11325/95 10/1994 Australia. TRANSFORMED CELLS INA 0284362 …
Methods for the detection of nucleic acids
AP Shuber, SN Lapidus, GQ Daley - US Patent 6,203,993, 2001 - Google Patents
US6203993B1 - Methods for the detection of nucleic acids - Google Patents US6203993B1 -
Methods for the detection of nucleic acids - Google Patents Methods for the detection of …
Methods for the detection of nucleic acids - Google Patents Methods for the detection of …
Methods for the detection of nucleic acids
AP Shuber, SN Lapidus - US Patent 6,300,077, 2001 - Google Patents
(63) Continuation-in-part of application No. 09/098,180,? led on Jun. 16, 1998, now
abandoned, which is a continuation-in part of application No. 08/876,857,? led on Jun. 16 …
abandoned, which is a continuation-in part of application No. 08/876,857,? led on Jun. 16 …
Linear-After-The-Exponential (LATE)-PCR: primer design criteria for high yields of specific single-stranded DNA and improved real-time detection
KE Pierce, JA Sanchez, JE Rice… - Proceedings of the …, 2005 - National Acad Sciences
Traditional asymmetric PCR uses conventional PCR primers at unequal concentrations to
generate single-stranded DNA. This method, however, is difficult to optimize, often …
generate single-stranded DNA. This method, however, is difficult to optimize, often …
Methods for disease diagnosis from stool samples
SN Lapidus, AP Shuber - US Patent 5,952,178, 1999 - Google Patents
The present invention provides methods for preparing a stool sample in order to screen for
the presence of indicators of a disease, for example a subpopulation of cancerous or …
the presence of indicators of a disease, for example a subpopulation of cancerous or …
Real-time PCR microfluidic devices with concurrent electrochemical detection
TH Fang, N Ramalingam, D Xian-Dui, TS Ngin… - Biosensors and …, 2009 - Elsevier
Electrochemistry-based detection methods hold great potential towards development of
hand-held nucleic-acid analyses instruments. In this work, we demonstrate the …
hand-held nucleic-acid analyses instruments. In this work, we demonstrate the …
Methods for detecting nucleic acids indicative of cancer
AP Shuber - US Patent 6,964,846, 2005 - Google Patents
The invention provides methods for Screening tissue or body fluid Samples for nucleic acid
indicia of cancer or precancer. Method are provided for Screening a patient for cancer or …
indicia of cancer or precancer. Method are provided for Screening a patient for cancer or …
Rapid detection of selected aneuploidies by quantitative fluorescent PCR
M Adinolfi, J Sherlock, B Pertl - Bioessays, 1995 - Wiley Online Library
Selected aneuploidies can be rapidly diagnosed by the analysis of fluorescent polymerase
chain reaction (PCR) products of chromosome‐specific and highly polymorphic small …
chain reaction (PCR) products of chromosome‐specific and highly polymorphic small …