N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Periodontitis is a chronic inflammatory disease that causes damage to periodontal tissues,
which include the gingiva, periodontal ligament, and alveolar bone. The major cause of …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Diabetic nephropathy (DN) is a research priority for scientists around the world because of
its high prevalence and poor prognosis. Although several mechanisms have been shown to …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …