Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein
Peripheral membrane proteins associate reversibly with biological membranes that,
compared to protein binding partners, are structurally labile and devoid of specific binding …
compared to protein binding partners, are structurally labile and devoid of specific binding …
Site-directed fluorescence approaches for dynamic structural biology of membrane peptides and proteins
Membrane proteins mediate a number of cellular functions and are associated with several
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …
Dissection of the amyloid formation pathway in AL amyloidosis
P Kazman, RM Absmeier, H Engelhardt… - Nature …, 2021 - nature.com
In antibody light chain (AL) amyloidosis, overproduced light chain (LC) fragments
accumulate as fibrils in organs and tissues of patients. In vitro, AL fibril formation is a slow …
accumulate as fibrils in organs and tissues of patients. In vitro, AL fibril formation is a slow …
Interaction of food colorant indigo carmine with human and bovine serum albumins: A multispectroscopic, calorimetric, and theoretical investigation
In this work we have studied the interaction of the food dye Indigo-Carmine (IndC) with the
most studied model transport proteins ie human and bovine serum albumin (HSA & BSA). A …
most studied model transport proteins ie human and bovine serum albumin (HSA & BSA). A …
Biophysical and molecular modelling analysis of the binding of β-resorcylic acid with bovine serum albumin
The bovine serum albumin (BSA) is a model carrier protein that transports and deposits the
various endogenous and exogenous ligands in the body. β-resorcylic acid (BR) is a phyto …
various endogenous and exogenous ligands in the body. β-resorcylic acid (BR) is a phyto …
Does Viscosity Decoupling Guarantee Dynamic Heterogeneity? A Clue through an Excitation and Emission Wavelength-Dependent Time-Resolved Fluorescence …
Traditionally, deviation from Stokes–Einstein–Debye (SED) relation in terms of viscosity
dependence of medium dynamics, ie, τ x∝(η T) p with p≠ 1, is taken as a signature of …
dependence of medium dynamics, ie, τ x∝(η T) p with p≠ 1, is taken as a signature of …
The dynamism of intrinsically disordered proteins: binding-induced folding, amyloid formation, and phase separation
S Mukhopadhyay - The Journal of Physical Chemistry B, 2020 - ACS Publications
Intrinsically disordered proteins (IDPs) or natively unfolded proteins do not undergo
autonomous folding into a well-defined 3-D structure and challenge the conventional …
autonomous folding into a well-defined 3-D structure and challenge the conventional …
Lysozyme–luteolin binding: molecular insights into the complexation process and the inhibitory effects of luteolin towards protein modification
In the proposed work, the complexation of bioactive flavonoid luteolin with hen egg white
lysozyme (HEWL) along with its inhibitory influence on HEWL modification has been …
lysozyme (HEWL) along with its inhibitory influence on HEWL modification has been …
Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic method
A Laguerre, JMY Wong, D Monchaud - Scientific reports, 2016 - nature.com
Guanine-rich DNA or RNA sequences can fold into higher-order, four-stranded structures
termed quadruplexes that are suspected to play pivotal roles in cellular mechanisms …
termed quadruplexes that are suspected to play pivotal roles in cellular mechanisms …
Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide
The permeability barrier of nuclear pore complexes (NPCs) controls nucleocytoplasmic
transport. It retains inert macromolecules while allowing facilitated passage of importins and …
transport. It retains inert macromolecules while allowing facilitated passage of importins and …