The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Protein disulfide isomerase (PDI), is a member of the thioredoxin superfamily of redox
proteins. PDI has three catalytic activities including, thiol-disulfide oxireductase, disulfide …

Collagen, the most abundant protein in animals, is a key component of extracellular
matrices. Not only do collagens provide essential structural support for connective tissues …

The fibrous collagens form the structural basis of all mammalian connective tissues,
including the vasculature, dermis, bones, tendons, cartilage, and those tissues that support …

Collagen is a major component of the extracellular matrix and plays a wide variety of
important roles in blood clotting, healing, and tissue remodeling. Natural, animal derived …

Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial
collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can …

Essentials• Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on
resting platelets.• Spatio‐temporal organization of platelet GPVI‐dimers was evaluated …

Collagen is a fascinating system of proteins that undergo a multi-step, hierarchical self-
assembly which starts from individual peptide chains that assemble into a canonical triple …

Interaction of von Willebrand factor (VWF) with platelet glycoprotein Ib (GPIb) and interaction
of collagen with GPVI are essential for thrombus formation on ruptured or eroded …