Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection
C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …
growth, and maintenance of neurons in key brain circuits involved in emotional and …
BDNF–a key transducer of antidepressant effects
C Björkholm, LM Monteggia - Neuropharmacology, 2016 - Elsevier
How do antidepressants elicit an antidepressant response? Here, we review accumulating
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …
A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression
P Riva-Posse, KS Choi, PE Holtzheimer… - Molecular …, 2018 - nature.com
Target identification and contact selection are known contributors to variability in efficacy
across different clinical indications of deep brain stimulation surgery. A retrospective …
across different clinical indications of deep brain stimulation surgery. A retrospective …
Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications
MP Dandekar, AJ Fenoy, AF Carvalho, JC Soares… - Molecular …, 2018 - nature.com
Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …
disease (PD), essential tremor and movement disorders, its effectiveness for the …
Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression
Background Subcallosal cingulate white matter (SCC) deep brain stimulation (DBS) is an
evolving investigational treatment for depression. Mechanisms of action are hypothesized to …
evolving investigational treatment for depression. Mechanisms of action are hypothesized to …
The habenula: from stress evasion to value-based decision-making
O Hikosaka - Nature reviews neuroscience, 2010 - nature.com
Surviving in a world with hidden rewards and dangers requires choosing the appropriate
behaviours. Recent discoveries indicate that the habenula plays a prominent part in such …
behaviours. Recent discoveries indicate that the habenula plays a prominent part in such …
Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
The cellular basis of depressive disorders is poorly understood. Recent studies in monkeys
indicate that neurons in the lateral habenula (LHb), a nucleus that mediates communication …
indicate that neurons in the lateral habenula (LHb), a nucleus that mediates communication …
[HTML][HTML] Lateral habenula in the pathophysiology of depression
Depression is a devastating disorder with a combination of diverse symptoms such as low
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …
Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient
Discussion. The DBS procedure resulted in a sustained full remission of depressive
symptoms in a patient who was therapyresistant to all standard treatments for at least 9 …
symptoms in a patient who was therapyresistant to all standard treatments for at least 9 …
Basal forebrain projections to the lateral habenula modulate aggression reward
Maladaptive aggressive behaviour is associated with a number of neuropsychiatric
disorders and is thought to result partly from the inappropriate activation of brain reward …
disorders and is thought to result partly from the inappropriate activation of brain reward …