Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …

Given that most bone marrow cells are short-lived, the accumulation of multiple
leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Bladder cancer is one of the most common cancers worldwide, with transitional cell
carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …