Cellular function and behavior are affected by the partial pressure of O2, or oxygen tension,
in the microenvironment. The level of oxygenation is important, as it is a balance of oxygen …

How do we understand neuronal signaling in the brain, how neurons control behavior, or
how signaling malfunctions during disease? Neuroscientists might take two approaches …

The African naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle
generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours …

As microfabrication techniques and tissue engineering methods improve, microphysiological
systems (MPS) are being engineered that recapitulate complex physiological and …

Gaseous microenvironments play important roles in various biological activities in vivo.
However, it is challenging to precisely control gaseous microenvironments in vitro for cell …

Ex vivo brain slice cultures are utilized as analytical models for studying neurophysiology.
Common approaches to maintaining slice cultures include roller tube and membrane …

Objective. Multi-photon laser scanning microscopy provides a powerful tool for monitoring
the spatiotemporal dynamics of neural circuit activity. It is, however, intrinsically a point …

Hydrogen sulfide (H2S) plays an important role as an intercellular and intracellular signaling
molecule, yet its targets are not well understood. As a molecule it easily evaporates and it is …

Providing primary human stem cells with the optimal environmental factors required to
promote expansion and differentiation is no trivial task in biomedical research. Many …

The bottleneck for drug discovery and drug screening has prompted the recent surge for
organ-on-a-chip 3D in vitro models that recapitulate physiological and disease mechanisms …