Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …

Previous genome-wide scans of positive natural selection in humans have identified a
number of non-neutrally evolving genes that play important roles in skin pigmentation …

An immune response consists of a finely orchestrated interplay between initial recognition of
potential microbial threats by the innate immune system and subsequent licensed adaptive …

Pro-inflammatory cytokines are crucial for fighting infection and establishing immunity.
Recently, other proteins, such as danger-associated molecular patterns (DAMPs), have also …

Malaria kills close to a million people every year, mostly children under the age of five. In the
drive towards the development of an effective vaccine and new chemotherapeutic targets for …

Cyclic paroxysm and high fever are hallmarks of malaria and are associated with high levels
of pyrogenic cytokines, including IL-1β. In this report, we describe a signature for the …