Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism,
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …

During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-
existing vascular network and guides following and proliferating stalk cells to form a new …

Glioblastomas (GBM) are highly aggressive primary brain tumors. Complex and dynamic
tumor microenvironment (TME) plays a crucial role in the sustained growth, proliferation, and …

The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …

Background Uncontrolled seizures in patients with gliomas have a significant impact on
quality of life and morbidity, yet the mechanisms through which these tumors cause seizures …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Cellular metabolism plays a central role in the regulation of both innate and adaptive
immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or …

The identification of recurrent point mutations in the isocitrate dehydrogenase 1 (IDH1)
gene, albeit in only a small percentage of glioblastomas a decade ago, has transformed our …

Altered central carbon metabolism is a hallmark of many diseases including diabetes,
obesity, heart disease and cancer. Identifying metabolic changes will open opportunities for …