Snake venom toxins: toxicity and medicinal applications

YS Chan, RCF Cheung, L Xia, JH Wong, TB Ng… - Applied microbiology …, 2016 - Springer
Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of
them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic …

[HTML][HTML] Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

Minor snake venom proteins: Structure, function and potential applications

J Boldrini-França, CT Cologna, MB Pucca… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Snake venoms present a great diversity of pharmacologically active compounds that may be
applied as research and biotechnological tools, as well as in drug development and …

Hyaluronidases and hyaluronate lyases: From humans to bacteriophages

M Sindelar, J Jilkova, L Kubala, V Velebny… - Colloids and Surfaces B …, 2021 - Elsevier
Hyaluronan is a non-sulfated negatively-charged linear polymer distributed in most parts of
the human body, where it is located around cells in the extracellular matrix of connective …

Wasp venomic: Unravelling the toxins arsenal of Polybia paulista venom and its potential pharmaceutical applications

A Perez-Riverol, JRA dos Santos-Pinto, AM Lasa… - Journal of …, 2017 - Elsevier
Abstract Polybia paulista (Hymenoptera: Vespidae) is a neotropical social wasp from
southeast Brazil. As most social Hymenoptera, venom from P. paulista comprises a complex …

[HTML][HTML] Separation and Analytical Techniques Used in Snake Venomics: A Review Article

C Sahyoun, M Rima, C Mattei, JM Sabatier, Z Fajloun… - Processes, 2022 - mdpi.com
The deleterious consequences of snake envenomation are due to the extreme protein
complexity of snake venoms. Therefore, the identification of their components is crucial for …

[HTML][HTML] Determination of hyaluronidase activity in Tityus spp. Scorpion venoms and its inhibition by Brazilian antivenoms

C Guerra-Duarte, CCR Horta, BBR Oliveira-Mendes… - Toxicon, 2019 - Elsevier
Hyaluronidases (HYALs) are enzymes ubiquitously found in venoms from diverse animals
and seem to be related to venom spreading. HYAL activity might be important to Tityus spp …

[HTML][HTML] Isolation, N-glycosylations and Function of a Hyaluronidase-Like Enzyme from the Venom of the Spider Cupiennius salei

O Biner, C Trachsel, A Moser, L Kopp… - PLoS …, 2015 - journals.plos.org
Structure of Cupiennius salei venom hyaluronidase Hyaluronidases are important venom
components acting as spreading factor of toxic compounds. In several studies this spreading …

[HTML][HTML] Partial in vitro analysis of toxic and antigenic activities of eleven Peruvian pitviper snake venoms

C Guerra-Duarte, J Lopes-Peixoto… - Toxicon, 2015 - Elsevier
This work used eleven Peruvian snake venoms (Bothrops andianus, Bothrops atrox,
Bothrops barnetti, Bothrops castelnaudi, Bothriopsis chloromelas, Bothrocophias …

Biochemical and molecular characterization of the hyaluronidase from Bothrops atrox Peruvian snake venom

DE Vivas-Ruiz, EE Gonzalez-Kozlova, J Delgadillo… - Biochimie, 2019 - Elsevier
Snake venoms are a rich source of enzymes such as metalloproteinases, serine proteinases
phospholipases A2 and myotoxins, that have been well characterized structurally and …