In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

Every year, more than 8000 new cases of chronic myeloid leukemia (CML) are diagnosed in
the United States. 1 BCR-ABL1, a fusion protein kinase derived from a reciprocal …

Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion
gene resulting from the t (9; 22)(q34; q11) chromosomal translocation, is thought to be the …

Simple Summary Chronic myeloid leukaemia (CML) is a type of blood cancer that is
currently well-managed with drugs that target cancer-causing proteins. However, a …

Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to
persistent β-catenin activation, remain formidable challenges for chronic myeloid leukemia …

The constitutively active BCR-ABL1 tyrosine kinase, found in t (9; 22)(q34; q11)
chromosomal translocation-derived leukemia, initiates an extremely complex signaling …

Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 have revolutionized therapy for
chronic myeloid leukemia (CML), paving the way for clinical development in other diseases …

Aberrant expression of long noncoding RNA (lncRNA) HULC is associated with various
human cancers. However, the role of HULC in chronic myeloid leukemia (CML) is unknown …