Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for
identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple …

The genetically tractable model organism Caenorhabditis elegans was first used to model
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C.
elegans recognizes and responds to viral, bacterial, and fungal infections. Components of …

Memory was traditionally considered an exclusive hallmark of adaptive immunity. This
dogma was challenged by recent reports that myeloid cells can retain 'memory'of earlier …

The nematode Caenorhabditis elegans has been a powerful experimental organism for
almost half a century. Over the past 10 years, researchers have begun to exploit the power …

The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …