Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
K Chamoto, T Yaguchi, M Tajima, T Honjo - Nature Reviews …, 2023 - nature.com
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …
[HTML][HTML] Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts
Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
Differentiation and maintenance of recirculating effector memory CD8 T cells (T EM)
depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation …
depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation …
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
During immune responses, T cells are subject to clonal competition, which leads to the
predominant expansion of high-affinity clones; however, there is little understanding of how …
predominant expansion of high-affinity clones; however, there is little understanding of how …
[HTML][HTML] Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC
chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked …
chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked …
Transcriptional repressor Blimp-1 promotes CD8+ T cell terminal differentiation and represses the acquisition of central memory T cell properties
RL Rutishauser, GA Martins, S Kalachikov, A Chandele… - Immunity, 2009 - cell.com
During acute infections, a small population of effector CD8+ T cells evades terminal
differentiation and survives as long-lived memory T cells. We demonstrate that the …
differentiation and survives as long-lived memory T cells. We demonstrate that the …
[HTML][HTML] Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment
KE Pauken, O Shahid, KA Lagattuta… - Journal of Experimental …, 2021 - rupress.org
Disclosures: K. Tsai reported personal fees from Regeneron, grants from Array/Pfizer, grants
from Replimune, and grants from Oncosec outside the submitted work. M. Rosenblum …
from Replimune, and grants from Oncosec outside the submitted work. M. Rosenblum …
Diversity in T cell memory: an embarrassment of riches
SC Jameson, D Masopust - Immunity, 2009 - cell.com
The adaptive immune response meets the needs of the organism to generate effector cells
capable of controlling pathogens but also leads to production of memory cells, which …
capable of controlling pathogens but also leads to production of memory cells, which …
[HTML][HTML] The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection
The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …