Engineering cell–cell communication networks: programming multicellular behaviors

S Toda, NW Frankel, WA Lim - Current opinion in chemical biology, 2019 - Elsevier
Cell–cell communication governs the biological behaviors of multicellular populations such
as developmental and immunological systems. Thanks to intense genetic analytical studies …

In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

Z Fu, X Zhang, X Zhou, U Ur-Rehman, M Yu, H Liang… - Cell research, 2021 - nature.com
RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs
and delivery with artificial vehicles or conjugated ligands; both have not solved the problem …

Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs

L Zhang, T Wu, Y Shan, G Li, X Ni, X Chen, X Hu, L Lin… - Brain, 2021 - academic.oup.com
Huntington's disease is an autosomal-dominant neurodegenerative disease caused by CAG
expansion in exon 1 of the huntingtin (HTT) gene. Since mutant huntingtin (mHTT) protein is …

Programmable biomolecular switches for rewiring flux in Escherichia coli

C Gao, J Hou, P Xu, L Guo, X Chen, G Hu, C Ye… - Nature …, 2019 - nature.com
Synthetic biology aims to develop programmable tools to perform complex functions such as
redistributing metabolic flux in industrial microorganisms. However, development of protein …

Engineering and modeling of multicellular morphologies and patterns

H Kim, X Jin, DS Glass, IH Riedel-Kruse - Current opinion in genetics & …, 2020 - Elsevier
Synthetic multicellular (MC) systems have the capacity to increase our understanding of
biofilms and higher organisms, and to serve as engineering platforms for developing …

Assembly of multi‐spheroid cellular architectures by programmable droplet merging

H Cui, X Wang, J Wesslowski, T Tronser… - Advanced …, 2021 - Wiley Online Library
Artificial multicellular systems are gaining importance in the field of tissue engineering and
regenerative medicine. Reconstruction of complex tissue architectures in vitro is …

Computational approaches to design and test plant synthetic metabolic pathways

A Küken, Z Nikoloski - Plant Physiology, 2019 - academic.oup.com
Successfully designed and implemented plant-specific synthetic metabolic pathways hold
promise to increase crop yield and nutritional value. Advances in synthetic biology have …

DNA Reaction Circuits to Establish Designated Biological Functions in Multicellular Community

Q Zhang, Y Zhang, L Wu, D Wang, Y Zhuo, Y Lu… - Nano Letters, 2024 - ACS Publications
In multicellular organisms, individual cells are coordinated through complex communication
networks to accomplish various physiological tasks. Aiming to establish new biological …

How to Grow a Human

P Ball - William Collins, London, 2019 - toc.library.ethz.ch
HOW TO GROW A HUMAN Page 1 HOW TO GROW A HUMAN ADVENTURES IN HOW WE
ARE MADE AND WHO WE ARE PHILIP BALL THE UNIVERSITY OF CHICAGO PRESS Page …

Design, Evaluation, and Implementation of Synthetic Isopentyldiol Pathways in Escherichia coli

Y Liu, L Chen, P Liu, Q Yuan, C Ma, W Wang… - ACS Synthetic …, 2023 - ACS Publications
Isopentyldiol (IPDO) is an important raw material in the cosmetic industry. So far, IPDO is
exclusively produced through chemical synthesis. Growing interest in natural personal care …