The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-
platform deep molecular investigation of 80 uveal melanoma primary tissue samples …

The claudin-low breast cancer subtype is defined by gene expression characteristics and
encompasses a remarkably diverse range of breast tumors. Here, we investigate genomic …

Introduction Triple negative breast cancer (TNBC) is a heterogeneous collection of
biologically diverse cancers, which contributes to variable clinical outcomes. Previously, we …

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …

After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor,
GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the …

High-grade serous ovarian cancer is characterized by extensive copy number alterations,
among which the amplification of MYC oncogene occurs in nearly half of tumors. We …

Melanoma is the deadliest form of commonly encountered skin cancer because of its rapid
progression towards metastasis,. Although metabolic reprogramming is tightly associated …

Human lung adenocarcinomas (LUAD) contain mutations in EGFR in∼ 15% of cases and in
KRAS in∼ 30%, yet no individual adenocarcinoma appears to carry activating mutations in …

Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase
(MAPK) pathway have led to clinical responses in lung and other cancers, but some patients …

NRF2 is emerging as a major regulator of cellular metabolism. However, most studies have
been performed in cancer cells, where co-occurring mutations and tumor selective …