Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety
R Zhang, S Xie, J Ran, T Li - Journal of Cellular Physiology, 2024 - Wiley Online Library
Abstract Proteolysis Targeting Chimeras (PROTACs) represent a significant advancement in
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability
H Wu, J Murray, N Ishisoko, A Frommlet… - Journal of Medicinal …, 2024 - ACS Publications
The von Hippel–Lindau (VHL) protein plays a pivotal role in regulating the hypoxic stress
response and has been extensively studied and utilized in the targeted protein degradation …
response and has been extensively studied and utilized in the targeted protein degradation …