Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated
ion channels and function as such in the central and peripheral nervous systems. Recently …

Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic
targets for the treatment of pain and inflammation, but despite more than 30 years of …

Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a
chemical signal into one that is electrical via ligand-gated ion flux through the central …

Aging is an important risk factor for neurodegenerative diseases. The activation of α7
nicotinic acetylcholine receptor (α7nAChR) is involved in inflammation and cognition, but the …

Abstract Pannexin‐1 (Panx1) forms plasma membrane channels that allow the exchange of
small molecules between the intracellular and extracellular compartments, and are involved …

Ligands that selectively inhibit human α 3 β 2 and α 6 β 2 nicotinic acetylcholine receptor
(nAChRs) and not the closely related α 3 β 4 and α 6 β 4 subtypes are lacking. Current α …

Adrenal chromaffin cells release neurotransmitters in response to stress and may be
involved in conditions such as post‐traumatic stress and anxiety disorders. Neurotransmitter …

In the present study, we have electrophysiologically characterized native nicotinic
acetylcholine receptors (nAChRs) in human chromaffin cells of the adrenal gland as well as …

An increase in circulating catecholamines constitutes one of the mechanisms whereby
human body responds to stress. In response to chronic stressful situations, the adrenal …