Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
Electrochemical transformations catalyzed by cytochrome P450s and peroxidases
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations
R Bernhardt, VB Urlacher - Applied microbiology and biotechnology, 2014 - Springer
Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …
Enzymatic Hydroxylations of sp3-Carbons
Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
Versatile biocatalysis of fungal cytochrome P450 monooxygenases
Abstract Cytochrome P450 (CYP) monooxygenases, the nature's most versatile biological
catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a …
catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a …
[HTML][HTML] Cytochrome P450-mediated metabolic engineering: current progress and future challenges
Highlights•P450s catalyze critical steps in all branches of plant specialized
metabolism.•P450-driven engineering has been successful in both microorganisms and …
metabolism.•P450-driven engineering has been successful in both microorganisms and …
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
SL Kelly, DE Kelly - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …
What makes a P450 tick?
The cytochromes P450 (P450s) are probably nature's most versatile enzymes in terms of
both their vast substrate range and the diverse types of molecular transformations performed …
both their vast substrate range and the diverse types of molecular transformations performed …
Cytochrome P450 (CYP) enzymes and the development of CYP biosensors
E Schneider, DS Clark - Biosensors and Bioelectronics, 2013 - Elsevier
Cytochrome P450s (CYPs) are a large family of heme-containing monooxygenase enzymes
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …
Natural compounds as pharmaceuticals: the key role of cytochromes P450 reactivity
G Di Nardo, G Gilardi - Trends in Biochemical Sciences, 2020 - cell.com
The design of drugs from natural products is a re-emerging area due to the need for
bioactive compounds. The exploitation of natural products and their derivatives obtained by …
bioactive compounds. The exploitation of natural products and their derivatives obtained by …