Engineered autonomous dynamic regulation of metabolic flux

M Ream, KLJ Prather - Nature Reviews Bioengineering, 2024 - nature.com
Metabolic engineering is a powerful tool to reprogramme cells to produce value-added
chemicals. Such engineering strategies require the fine-tuning of a cell's metabolism to …

Bacterial transcription factors bind to coding regions and regulate internal cryptic promoters

C Hua, J Huang, T Wang, Y Sun, J Liu, L Huang… - Mbio, 2022 - Am Soc Microbiol
Transcription factors (TFs) regulate transcription by binding to the specific sequences at the
promoter region. However, the mechanisms and functions of TFs binding within the coding …

Characterization of an Entner–Doudoroff pathway-activated Escherichia coli

YE Kim, KH Cho, I Bang, CH Kim, YS Ryu… - … for Biofuels and …, 2022 - Springer
Background Escherichia coli have both the Embden–Meyerhof–Parnas pathway (EMPP)
and Entner–Doudoroff pathway (EDP) for glucose breakdown, while the EDP primarily …

Deep-learning optimized DEOCSU suite provides an iterable pipeline for accurate ChIP-exo peak calling

I Bang, SM Lee, S Park, JY Park, LK Nong… - Briefings in …, 2023 - academic.oup.com
Recognizing binding sites of DNA-binding proteins is a key factor for elucidating
transcriptional regulation in organisms. ChIP-exo enables researchers to delineate genome …

Model-driven experimental design workflow expands understanding of regulatory role of Nac in Escherichia coli

JY Park, SM Lee, A Ebrahim… - NAR genomics and …, 2023 - academic.oup.com
The establishment of experimental conditions for transcriptional regulator network (TRN)
reconstruction in bacteria continues to be impeded by the limited knowledge of activating …

[Retracted] Comprehensive and Integrated Analysis Identifies ZEB1 as a Key Novel Gene in Oral Squamous Cell Carcinoma

J Ma, Y Yao, D Tao, J Yin, L Chen, Y Cui… - Contrast Media & …, 2022 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with a
poor prognosis. Therefore, it is crucial to explore molecular prognostic biomarkers for OSCC …

Elucidating DNA-binding protein dynamics in Salmonella Typhimurium within macrophages using a breakthrough low-input ChIP-exo approach

JY Park, M Jang, E Choi, SM Lee, I Bang, J Woo, S Kim… - bioRxiv, 2024 - biorxiv.org
Genome-wide identification of binding profiles for DNA-binding proteins in Salmonella
Typhimurium within macrophages is crucial for understanding virulence gene expression …