Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

SL Kordus, AK Thomas, DB Lacy - Nature Reviews Microbiology, 2022 - nature.com
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

E Van Nood, A Vrieze, M Nieuwdorp… - … England Journal of …, 2013 - Mass Medical Soc
Background Recurrent Clostridium difficile infection is difficult to treat, and failure rates for
antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in …

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

E Weglarz-Tomczak, JM Tomczak, M Talma… - Scientific reports, 2021 - nature.com
An efficient treatment against a COVID-19 disease, caused by the novel coronavirus SARS-
CoV-2 (CoV2), remains a challenge. The papain-like protease (PLpro) from the human …

Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

M Zimmermann, KR Patil, A Typas… - Molecular systems …, 2021 - embopress.org
Broad‐spectrum antibiotics target multiple gram‐positive and gram‐negative bacteria, and
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Capturing the environment of the Clostridioides difficile infection cycle

MK Schnizlein, VB Young - Nature Reviews Gastroenterology & …, 2022 - nature.com
Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N6-Methyladenosine-Modified RNAs

M Micaelli, A Dalle Vedove, L Cerofolini… - ACS Pharmacology & …, 2022 - ACS Publications
YTHDF proteins bind the N 6-methyladenosine (m6A)-modified mRNAs, influencing their
processing, stability, and translation. Therefore, the members of this protein family play …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …