Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Acute central nervous system injuries (ACNSI), encompassing traumatic brain injury (TBI),
non-traumatic brain injury like stroke and encephalomeningitis, as well as spinal cord …

Background Microglial activation-mediated neuroinflammation is a major contributor to early
brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the …

Background The essential oils possess both antimicrobial and anti-inflammatory effects,
therefore they can provide an effective treatment against infections. Essential oils are widely …

Neuroinflammation and microglial iron load are significant hallmarks found in several
neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron …

Huntington's disease (HD) is an inherited neurodegenerative disorder in which the striatum
is the most affected brain region. Although a chronic inflammatory microglial reaction that …

The hormone hepcidin plays a central role in controlling iron homeostasis. Iron-mediated
hepcidin synthesis is triggered via the BMP/SMAD pathway. At inflammation, mainly IL-6 pro …

Reactive microglia are suggested to be involved in neurological disorders, and the
mechanisms underlying microglial activity may provide insights into therapeutic strategies …

The mitochondrial flavoprotein ferredoxin reductase (FDXR) is required for biogenesis of
iron–sulfur clusters and for steroidogenesis. Iron–sulfur (Fe–S) clusters are ubiquitous …

Following insults or injury, microglia cells are activated contributing to the cytotoxic response
or by promoting an immune-mediated damage resolution. Microglia cells express HCA2R, a …