Fasciola hepatica is a trematode parasite with a global distribution, which is responsible for
considerable disease and production losses in a range of food producing species. It is also …

Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

The survival of helminths in the host over long periods of time is the result of a process of
adaptation or dynamic co-evolution between the host and the parasite. However, infection …

The liver fluke, Fasciola hepatica, causes fascioliasis in domestic animals (sheep, cattle), a
global disease that is also an important infection of humans. As soon as the parasite invades …

Helminth parasites are highly successful pathogens, chronically infecting a quarter of the
world's population, causing significant morbidity but rarely causing death. Protective …

Helminth parasites secrete extracellular vesicles (EVs) that can be internalised by host
immune cells resulting in modulation of host immunity. While the molecular cargo of EVs …

Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by
Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication …

Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its
mammalian host. The parasite releases a large number of molecules that are critical to …

Parasite-released extracellular vesicles (EVs) deliver signals to the host immune system that
are critical to maintaining the long-term relationship between parasite and host. In the …

Human monocyte-derived dendritic cells (DCs) show remarkable phenotypic changes upon
direct contact with soluble products (SPs) of Trichuris suis, a pig whipworm that is …