Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

IMproving preclinical assessment of cardioprotective therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST action

S Lecour, I Andreadou, HE Bøtker… - Basic research in …, 2021 - Springer
Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the
leading causes of death and disability worldwide. As such, new therapeutic interventions are …

The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - ASPET
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Critical issues for the translation of cardioprotection

G Heusch - Circulation research, 2017 - Am Heart Assoc
The translation from numerous successful animal experiments on cardioprotection beyond
that by reperfusion to clinical practice has to date been disappointing. Animal experiments …

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

DJ Hausenloy, HE Botker, T Engstrom… - European heart …, 2017 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …

[HTML][HTML] Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities

SB Ong, S Hernández-Reséndiz… - Pharmacology & …, 2018 - Elsevier
Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of
death and disability worldwide. As such, new therapies are required to limit myocardial …

The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR) A New Paradigm for Rigorous, Accurate, and Reproducible …

SP Jones, XL Tang, Y Guo, C Steenbergen… - Circulation …, 2015 - Am Heart Assoc
Rationale: Despite 4 decades of intense effort and substantial financial investment, the
cardioprotection field has failed to deliver a single drug that effectively reduces myocardial …

ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies

S Lecour, HE Bøtker, G Condorelli… - Cardiovascular …, 2014 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide.
As a result, novel therapies are still needed to protect the heart from the detrimental effects of …

Mitochondrial transplantation in humans:“magical” cure or cause for concern?

E Bertero, C Maack, B O'Rourke - The Journal of clinical …, 2018 - Am Soc Clin Investig
Mitochondrial transplantation is a therapeutic approach developed by McCully and
colleagues that entails the injection of healthy mitochondria harvested from unaffected tissue …