Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular
zone of the dentate gyrus is regulated negatively by stressful experiences and positively by …

Although major depressive disorder is primarily considered a mood disorder, depressed
patients commonly present with clinically significant cognitive dysfunction that may add to …

This study aimed to investigate the influence of genetic variants in neuroplasticity-related
genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well …

Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …

Mood disorders are not merely attributed to the functional defect of neurotransmission, but
also are due to the structural impairment of neuroplasticity. Chronic stress decreases …

Adenosine monophosphate-activated protein kinase (AMPK) is critical for whole-body
energy metabolism regulation. Recent studies have suggested that physical exercise …

It has been recently suggested that activation of 5-HT4 receptors might exert antidepressant-
like effects in rats after 3 d treatment, suggesting a new strategy for developing faster-acting …

It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …

Preclinical studies support a critical role of 5-HT 4 receptors (5-HT 4 Rs) in depression and
anxiety, but their influence in depression-and anxiety-like behaviours and the effects of …