The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …

The indolocarbazoles are an important class of nitrogen heterocycles which has evolved
significantly in recent years, with numerous studies focusing on their diverse biological …

The aryl hydrocarbon receptor (AHR), a member of the basic helix–loop–helix (bHLH) Per–
Arnt–Sim (PAS) family of transcription factors, plays important roles in regulating xenobiotic …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the
effects of human‐mediated environmental changes, including environmental pollution. Here …

The aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT) constitute a
heterodimeric basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain containing …

The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix
transcription factor that binds structurally diverse ligands and senses cues from …

The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

The aryl hydrocarbon receptor (AHR) was for many years of interest only to pharmacologists
and toxicologists. However, this protein has fundamental roles in biology that are being …