Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …

Motivation Gene set enrichment analysis (GSEA) is a commonly used algorithm for
characterizing gene expression changes. However, the currently available tools used to …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Extracellular DNA traps (ETs) represent an immune response by which cells release
essential materials like chromatin and granular proteins. Previous studies have …

Liver organoids represent emerging human-relevant in vitro liver models that have a wide
range of biomedical applications in basic medical studies and preclinical drug discovery …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a growing cause of
morbidity with limited treatment options. Thus, accurate in vitro systems to test new therapies …