Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

Our appreciation of the scope and influence of second messenger signaling has its origins
in pioneering work on the cAMP-dependent protein kinase. Also called protein kinase A …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …

SPECIFICITY IN THE cAMP/PKA SIGNALING PATHWAY. DIFFERENTIAL EXPRESSION,
REGULATION, AND SUBCELLULAR LOCALIZATION OF SUBUNITS OF Page 1 [Frontiers in …

The complexity and specificity of many forms of signal transduction are widely suspected to
require spatial microcompartmentation of protein kinase and phosphatase activities, yet …

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …

Cellular functions are mediated through complex systems of macromolecules and
metabolites linked through biochemical and physical interactions, represented in …

Compartmentalization of signalling molecules through association with anchoring proteins
ensures specificity in signal transduction by placing enzymes close to their appropriate …