Proteoglycan macromolecules play key roles in several physiological processes (eg,
adhesion, proliferation, migration, invasion, angiogenesis, and apoptosis), all of which are …

Fetal growth restriction (FGR) is a complex disorder of human pregnancy that leads to poor
health outcomes in offspring. These range from immediate risks such as perinatal morbidity …

Objectives Placental insufficiency contributes to altered maternal-fetal amino acid transfer,
and thereby to poor fetal growth. An important placental function is the uptake of tryptophan …

Introduction Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate
proteoglycan expressed on the extracellular, luminal surface of epithelial cells and …

Objective The endothelial glycocalyx constitutes part of the endothelial barrier but its
degradation leaves endothelial cells exposed to transmigrating cells and circulating …

The process of embryo attachment and invasion through the endometrial epithelial cells and
subsequent implantation into the decidualized endometrial stroma is the groundbreaking …

The endothelial glycocalyx (EG) is a meshlike network present on the apical surface of the
endothelium. Membrane-bound proteoglycans, the major backbone molecules of the EG …

Objective The identification of fetal growth disorders is an important clinical priority given that
they increase the risk of perinatal morbidity and mortality as well as long-term diseases. A …

Syndecan-3 is one of the four members of the syndecan family of heparan sulphate
proteoglycans and has been shown to interact with numerous growth factors via its heparan …

Glycosaminoglycans (GAGs) are heteropolysaccharides in mammalian tissue and consist of
repeated disaccharide units with mono-sulfated or non-sulfated monosaccharides. GAGs …