Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …

Simple Summary Previous clinical studies have suggested a relationship between
obstructive sleep apnea and some types of cancer. This relationship is very heterogeneous …

Background OSA has been associated with increased incidence and aggressiveness of
melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of …

Melanoma is the most aggressive of all skin cancers and carries a very high mortality rate.
Malignant transformation of melanocytes underlies the occurrence of this malignancy, which …

Effects of OSA on cancer may largely vary among neoplastic diseases, both in their
magnitude and direction. The worse risk associated with intermittent rather than persistent …

Background Melanoma is the most aggressive and lethal form of skin cancer. While
emerging in-vivo evidence suggests that intermittent hypoxia, a hallmark feature of …

Midkine (MDK) might mediate the proangiogenic effect of intermittent hypoxia (IH) in patients
with obstructive sleep apnea (OSA) and cutaneous melanoma (CM). We compare circulating …

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxic environments at the
cellular level and is an independent risk factor for the development of cardiovascular …