The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …

Natural killer (NK) cells are lymphocytes of the innate immune response characterized by
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …

The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive
natural killer (NK) cells, contributing to host defense. However, approximately 4% of all …

During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding
maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass …

Immune cell differentiation is critical for adequate tissue-specific immune responses to
occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells) …

Natural killer (NK) cell education, a process for achieving functional maturation and self-
tolerance, has been previously defined by the interaction between self-major …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) resulting from a breakdown in peripheral immune tolerance. Although a …

Inhibitory signaling during natural killer (NK) cell education translates into increased
responsiveness to activation; however, the intracellular mechanism for functional tuning by …

Natural killer (NK) cells are powerful immune effectors, modulating their anti-tumor function
through a balance activating and inhibitor ligands on their cell surface. Though still …