Pharmacological role of functionalized gold nanoparticles in disease applications

WC Ko, SJ Wang, CY Hsiao, CT Hung, YJ Hsu… - Molecules, 2022 - mdpi.com
Gold has always been regarded as a symbol of nobility, and its shiny golden appearance
has always attracted the attention of many people. Gold has good ductility, molecular …

Light-responsive biomaterials for ocular drug delivery

HAM Abdelmohsen, NA Copeland… - Drug Delivery and …, 2023 - Springer
Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic
acids, where the tunable/precise delivery of payload highlights the potential of such …

Model for gold nanoparticle synthesis: Effect of pH and reaction time

S Yazdani, A Daneshkhah, A Diwate, H Patel… - ACS …, 2021 - ACS Publications
The synthesis of gold nanoparticles is dependent on both the concentration of trisodium
citrate dihydrate and the time that it interacts with tetrachloroauric acid. A wide range of gold …

Nanoparticles in ocular applications and their potential toxicity

C Yang, J Yang, A Lu, J Gong, Y Yang, X Lin… - Frontiers in molecular …, 2022 - frontiersin.org
Nanotechnology has been developed rapidly in recent decades and widely applied in
ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current …

[HTML][HTML] Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

S Rojekar, S Parit, AD Gholap, A Manchare… - Pharmaceutics, 2024 - mdpi.com
Microneedle technology revolutionizes ocular drug delivery by addressing challenges in
treating ocular diseases. This review explores its potential impact, recent advancements …

Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?

M Salla, N Karaki, B El Kaderi, AJ Ayoub, S Younes… - Pharmaceutics, 2024 - mdpi.com
Overcoming the limited bioavailability and extensive metabolism of effective in vitro drugs
remains a challenge that limits the translation of promising drugs into clinical trials …

Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model

A Romeo, A Bonaccorso, C Carbone, G Lupo… - International Journal of …, 2022 - Elsevier
Melatonin (MEL) is a pleiotropic neurohormone of increasing interest as a neuroprotective
agent in ocular diseases. Improving the mucoadhesiveness is a proposed strategy to …

High-capacity mesoporous silica nanocarriers of siRNA for applications in retinal delivery

A Ultimo, M Orzaez, MJ Santos-Martinez… - International Journal of …, 2023 - mdpi.com
The main cause of subretinal neovascularisation in wet age-related macular degeneration
(AMD) is an abnormal expression in the retinal pigment epithelium (RPE) of the vascular …

[HTML][HTML] Progressing nanotechnology to improve diagnosis and targeted therapy of Diabetic Retinopathy

R Baghban, E Namvar, A Attar, M Mortazavi - Biomedicine & …, 2025 - Elsevier
The inherent limitations of traditional treatments for Diabetic Retinopathy (DR) have spurred
the development of various nanotechnologies, offering a safer and more efficient approach …

Discovery and potential utility of a novel non-invasive ocular delivery platform

W Wang, N Snider - Pharmaceutics, 2023 - mdpi.com
To this day, the use of oily eye drops and non-invasive retinal delivery remain a major
challenge. Oily eye drops usually cause ocular irritation and interfere with the normal …