Post marketing surveillance of suspected adverse drug reactions through spontaneous reporting: current status, challenges and the future

M Alomar, AM Tawfiq, N Hassan… - … advances in drug …, 2020 - journals.sagepub.com
Background: To highlight the importance of spontaneous reporting programs in post
marketing surveillance of medicines. Authors also aimed at providing various dimensions of …

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping

MC Campbell, SA Tishkoff - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

A critical perspective on 3D liver models for drug metabolism and toxicology studies

AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

[HTML][HTML] Pharmacogenomics: a genetic approach to drug development and therapy

R Qahwaji, I Ashankyty, NS Sannan, MS Hazzazi… - Pharmaceuticals, 2024 - mdpi.com
The majority of the well-known pharmacogenomics research used in the medical sciences
contributes to our understanding of medication interactions. It has a significant impact on …

Assessment of the Antioxidant and Antimicrobial Potential of Ptychotis verticillata Duby Essential Oil from Eastern Morocco: An In Vitro and In Silico Analysis

M Taibi, A Elbouzidi, D Ou-Yahia, M Dalli, R Bellaouchi… - Antibiotics, 2023 - mdpi.com
Ptychotis verticillata Duby, referred to as Nûnkha in the local language, is a medicinal plant
that is native to Morocco. This particular plant is a member of the Apiaceae family and has a …

The role of eukaryotic and prokaryotic ABC transporter family in failure of chemotherapy

R El-Awady, E Saleh, A Hashim, N Soliman… - Frontiers in …, 2017 - frontiersin.org
Over the years chemotherapy failure has been a vital research topic as researchers have
been striving to discover reasons behind it. The extensive studies carried out on …

[PDF][PDF] Role of pharmacovigilance in India: An overview

SG Suke, P Kosta, H Negi - Online journal of public health informatics, 2015 - ojphi.jmir.org
Pharmacovigilance (PV) plays a key role in the healthcare system through assessment,
monitoring and discovery of interactions amongst drugs and their effects in human …

[HTML][HTML] Phytochemical, antioxidant, and anticancer assessments of Atriplex halimus extracts: In silico and in vitro studies

M Roubi, A Elbouzidi, M Dalli, S Azizi, M Aherkou… - Scientific African, 2023 - Elsevier
In recent years, the global health community has become increasingly interested in
harnessing the therapeutic potential of traditional plants. This study focuses on Atriplex …

Effect of clonazepam and clonidine on primary sleep bruxism: a double‐blind, crossover, placebo‐controlled trial

T Sakai, T Kato, S Yoshizawa… - Journal of sleep …, 2017 - Wiley Online Library
The aim of this study was to assess the acute effects of clonazepam and clonidine on
rhythmic masticatory muscle activity in young adults with primary sleep bruxism, as well as …

Rational Molecular Design of a Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2D6

J Ning, Z Tian, J Wang, F Yan, C Shi… - Angewandte Chemie …, 2024 - Wiley Online Library
Abstract Cytochrome P450 2D6 (CYP2D6) is a key enzyme that mediates the metabolism of
various drugs and endogenous substances in humans. However, its biological role in drug …