Endosome maturation

J Huotari, A Helenius - The EMBO journal, 2011 - embopress.org
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Phosphoinositides, major actors in membrane trafficking and lipid signaling pathways

JO De Craene, DL Bertazzi, S Bär, S Friant - International journal of …, 2017 - mdpi.com
Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

PI5P and PI (3, 5) P2: minor, but essential phosphoinositides

J Hasegawa, BS Strunk, LS Weisman - Cell structure and function, 2017 - jstage.jst.go.jp
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions.
Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and …

Mammalian phosphoinositide kinases and phosphatases

T Sasaki, S Takasuga, J Sasaki, S Kofuji… - Progress in lipid …, 2009 - Elsevier
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

C Karabiyik, M Vicinanza, SM Son, DC Rubinsztein - Developmental Cell, 2021 - cell.com
Autophagy is an essential catabolic process induced to provide cellular energy sources in
response to nutrient limitation through the activation of kinases, like AMP-activated protein …

The Arabidopsis trithorax‐like factor ATX1 functions in dehydration stress responses via ABA‐dependent and ABA‐independent pathways

Y Ding, Z Avramova, M Fromm - The Plant Journal, 2011 - Wiley Online Library
Emerging evidence suggests that the molecular mechanisms driving the responses of plants
to environmental stresses are associated with specific chromatin modifications. Here, we …

Nuclear lipid signalling

RF Irvine - Nature Reviews Molecular Cell Biology, 2003 - nature.com
During the past twenty years, evidence has accumulated for the presence of phospholipids
within the nuclei of eukaryotic cells. These phospholipids are distinct from those that are …

Insulin action on glucose transporters through molecular switches, tracks and tethers

H Zaid, CN Antonescu, VK Randhawa… - Biochemical …, 2008 - portlandpress.com
Glucose entry into muscle cells is precisely regulated by insulin, through recruitment of
GLUT4 (glucose transporter-4) to the membrane of muscle and fat cells. Work done over …

Lipid sorting and multivesicular endosome biogenesis

C Bissig, J Gruenberg - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Intracellular organelles, including endosomes, show differences not only in protein but also
in lipid composition. It is becoming clear from the work of many laboratories that the …

Phosphoinositides in new spaces

EM Davies, CA Mitchell… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …