Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Vitamin E, which includes both tocopherols and tocotrienols, comprises lipid-soluble
antioxidants that modulate lipid peroxidation. Recently, significant advances have been …

Sustained agonist-induced production of the second messengers InsP 3 and diacylglycerol
requires steady delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER to …

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca2+ from
intracellular stores to activate stage-specific Ca2+-dependent protein kinases. Using the …

The membranes of mammalian cells contain hundreds of different phospholipid species, a
variety of glycolipids and cholesterol. While the reasons for such compositional diversity are …

The membranes of eukaryotic cells create hydrophobic barriers that control substance and
information exchange between the inside and outside of cells and between cellular …